What it isAn amino acid that enhances brain function, improves mood and balances neurotransmitters. It has powerful liver detoxifying and natural anti-inflammatory effects. There are two forms of SAMe: the less effective and less absorbable tosylate form, and the superior butanedisulfonate form.
What it does
SAMe (s-adenosyl-methionine) is available in various salts with the butanedisulfonate form being the most stable. SAMe is a naturally occurring molecule that occurs in virtually all tissues and fluids. SAMe functions primarily as a methyl donor. A wide variety of molecules accept SAMe’s methyl groups; naturally occurring recipients include proteins, phospholipids, DNA, RNA, hormones, and the energy transporting amino acid creatine. Methylation is essential to the development of the phospholipid bilayer that makes up the outer membranes of normal cells and thereby contributes to membrane fluidity. SAMe-mediation is also critical for the formation of neurotransmitters in the central nervous system. Hepatic transmethylation is also important: 85% of total body transmethylation occurs in the liver. After donating its methyl group, SAMe is converted to s-adenosylhomocysteine, which initiates the important transsulfuration pathway in the liver, resulting in the generation of glutathione, the most potent antioxidant in the liver. Both folate and vitamin B12 are essential co-nutrients in the metabolism and replenishment of SAMe. SAMe may be beneficial in joint regeneration due to analgesic and anti-inflammatory effects. Preliminary evidence suggests SAMe might stimulate articular cartilage growth and repair, specifically chondrocyte proteoglycan synthesis and proliferation rate. SAMe might also protect against cytokine induced cell damage.
How to Use
Adults and children over 12 years of age: Take 1 tablet once or twice daily. Take on an empty stomach (at least 30 minutes before a meal). Children 7-12 years of age: Take 1 tablet daily. These doses can be doubled if adequate benefit is not obtained after 2 months of use.
|(tablet is enteric coated to protect against stomach acid)|
Warnings, Side Effects, Contraindications, Product Interactions and Special Precautions:
Refer to product insert or visit the manufacturers website for more information
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