What it is
Boosts energy and mobilises fat. Supports memory and cognitive function.
Unique: contains the more effective PLC and arginate forms of Acetyl-L-Carnitine.
What it does
Acetyl-L-Carnitine (ALC) is a fatigue-fighting amino acid used by the mitochondria in cells to produce energy from fats. Studies show that ALC supports memory in age-related memory loss and cognitive function. Acetyl-L Carnitine-PLC™ contains two of the most effective forms of ALC, namely ALC-arginate and Propionyl-L-Carnitine (PLC).
Acetyl-L-carnitine is the acetylated form of L-carnitine with improved bioavailability. The main function of acetyl-L-carnitine is the mediation of transport of long-chain fatty acids across the inner mitochondrial membrane. First, long-chain fatty acids form esters with CoA (acyl-CoA) in a reaction catalyzed by acyl-CoA synthetase (palmitoyl-CoA in the case of palmitate) in the cytoplasm. The next enzyme, carnitine palmitoyl transferase I performs transesterification by producing fatty acyl-L-carnitine esters (palmitoyl-L-carnitine) on the external surface of the inner mitochondrial membrane. This enzyme is involved in muscle physiological adaptation and results in a reduction in the oxidation of fatty acids and increased glucose utilization. Transport of the long-chain fatty acyl-L-carnitine esters across the inner mitochondrial membrane is mediated by acylcarnitine translocase, a special transport system in exchange for free L-carnitine of mitochondrial origin. On the matrix side of the inner mitochondrial membrane, carnitine palmitoyl transferase II catalyzes regeneration of long-chain acyl-CoA (palmitoyl CoA) and it is this form that subsequently undergoes β-oxidation to provide energy. In skeletal and cardiac muscle, the medium chain fatty acids with eight to 12 carbons also require carnitine for oxidation. Acetyl-L-carnitine is structurally related to acetylcholine. It also serves as a precursor to acetyl coenzyme A, and supplies acetyl groups to acetylcholine making it superior to L-carnitine in this aspect. It also seems to promote acetylcholine release and increases choline acetyltransferase activity. Propionyl-L-carnitine also increases pyruvate flux into the Krebs Cycle, stimulates pyruvate dehydrogenase activity, has free radical scavenging activity, improves homeostasis in the coagulation cascade. Propionyl-L-carnitine improves energy, metabolism, and myocardial contractility in experimental models.
How to Use
Adults and children over 12 years of age: Take 1-2 capsules twice daily on an empty stomach, before 4pm.
Each capsule contains:
|Acetyl-L-Carnitine arginate dihydrochloride||350mg|
Inactive ingredients: Hypromellose (cellulose) vegetarian capsule shell (gelatin free), magnesium stearate (vegetarian flow agent) and silicon dioxide.
Warnings, Side Effects, Contraindications, Product Interactions and Special Precautions:
Refer to product insert or visit the manufacturers website for more information
Deliveries between 7-10 working days.
Free returns within 30 days of purchase.